Study connects psychological stress and depression with lasting cancer fatigue
A study reported by Wake Forest University and published in JAMA Network Open followed people receiving chemotherapy for breast cancer. The researchers found that perceived stress and depressive symptoms were important predictors of fatigue up to two years after treatment began, while the cardiac measures they examined were not the main explanation.
This does not mean fatigue is “all in the mind,” nor does an observational relationship prove that stress or depression causes fatigue. Cancer-related fatigue is real and can have several interacting contributors. The findings support treating the whole person and studying whether earlier supportive interventions can improve longer-term functioning.
Sources: Medical Xpress/Wake Forest report, September 1, 2026: https://medicalxpress.com/news/2026-09-stress-depression-heart-term-breast.html ; JAMA Network Open DOI: https://doi.org/10.1001/jamanetworkopen.2026.29862
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